hADM Skin Regeneration
Juveacell
Unlike skin boosters that ‘stimulate’ collagen with an ingredient, Juveacell places a matrix resembling human dermal structure — a scaffold for regeneration (hADM).
Duration
20–30 min
Pain
Area-dependent
Full-face moderate · under-eye mild
Downtime
2–3 days
Price
₩650,000~
8% ₩650k · V ₩750k
What is Juveacell?
Juveacell is a regenerative treatment using human acellular dermal matrix (hADM). Long used in body applications such as plastic and orthopedic surgery, it has recently seen growing use in facial aesthetics.
Unlike ordinary skin boosters that ‘stimulate’ collagen with a single ingredient, it places a matrix resembling the skin’s own dermal structure, into which fibroblasts move to create natural regeneration and volume. It also tends not to form nodules.
Source
Human acellular dermal matrix (hADM)
Decellularization
Supercritical CO₂ · surfactant-free
Trait
No nodules
Duration
About 3–6 months
How it works — a matrix, not just an ingredient
Cellular components are removed from donor human dermis while its ECM (collagen and structural proteins) scaffold is preserved. As shown below, once this acellular dermal matrix settles in the skin, fibroblasts move in to create regeneration and volume.
The supercritical CO₂ process (surfactant-free) removes cells with low cellular and chemical residue while preserving the dermal ECM. Rather than simply filling with an ingredient, it provides a scaffold resembling the dermis.
Rather than ‘stimulating’ with an ingredient, it provides a matrix resembling the dermal ECM scaffold itself as a foundation for regeneration.
The evidence
The science and regulation of hADM are described across the literature. Injectable hADM for facial aesthetics, however, is relatively new — the evidence includes small, early studies, and individual results are not guaranteed.
A review of ADM clinical applications describes implanted ADM being repopulated by host cells (fibroblasts, etc.), followed by increased collagen and elastin and the onset of revascularization.
Petrie et al., Scars Burns Heal, 2022 ↗An early study of injectable (micronized) acellular dermal matrix for facial soft-tissue augmentation observed histological invasion by host fibroblasts without foreign-body reaction.
Sclafani et al., Arch Facial Plast Surg, 2000 ↗In a 20-participant split-face study, the side treated with particulated hADM was reported to show improvements in skin-density, elasticity, wrinkle and hydration-related measures over 20 weeks (a small pilot).
Lee et al., Int J Mol Sci, 2026 (split-face) ↗Supercritical CO₂ decellularization is performed at low temperature, reducing ECM protein denaturation versus detergent methods; preclinically it was associated with reduced inflammatory cytokines and progressive fibroblast infiltration with new (type I/III) collagen over time.
Giang et al., Front Bioeng Biotechnol, 2024 ↗The source human dermis is classified in the U.S. as a human cell/tissue product (HCT/P), regulated by the FDA under 21 CFR Part 1271, with many supplied by AATB-accredited tissue banks.
eCFR — 21 CFR Part 1271 (HCT/P) · AATB ↗
Especially used for the under-eye
It is used for under-eye hollowing, dark circles and regeneration that other treatments struggled to improve. It is applied in a similar area to Rejuran Eye and Juvelook Eye; since the under-eye is a spot where nodules are especially unwelcome and Juveacell tends not to form nodules, it can be treated here as well.
Where it's used
- Full-face skin booster — shallow dermal injection for overall texture, elasticity and regeneration
- Under-eye (dark circles, hollowing, fine lines) — cannula technique, reassuring as it doesn't form nodules
- Depressed scars — tissue reconstruction for acne/chickenpox scars
- Volume loss / thinned skin — structural reinforcement and regeneration
Juveacell vs Rejuran vs Juvelook
| Juveacell (hADM) | Rejuran | Juvelook | |
|---|---|---|---|
| Concept | Supplies dermal matrix (ECM scaffold) | Stimulates via ingredient (PN/PDRN) | Stimulates via ingredient (PLLA) |
| Action | Scaffold for regeneration + volume | Texture, elasticity, renewal | Collagen build-up, volume |
| Nodules | None | None | Rarely possible |
| Under-eye | Hollowing & regeneration | Rejuran Eye | Juvelook Eye |
Not better-or-worse, but a difference in approach — Juveacell for under-eye and regeneration, Rejuran/Juvelook for texture and elasticity upkeep, decided through consultation.
Procedure & recovery
Treatment
Topical numbing, then full-face injection (moderate) or cannula under-eye (mild), ~20–30 min
First days
Swelling for 2–3 days (up to 1–2 weeks), but daily life is fine
After
Regeneration and volume settle; effect lasts about 3–6 months (varies)
Duration is about 3–6 months (individual variation); anesthesia is by topical numbing cream.
Safety & regulation
The source human dermis is managed by the U.S. FDA as a human cell/tissue product (HCT/P, 21 CFR Part 1271) and supplied by AATB-accredited tissue banks. Cellular components that could cause rejection or infection are removed, and the supercritical CO₂ method further reduces chemical residue to minimize immune and foreign-body reactions.
That said, because it uses human tissue, we recommend ongoing follow-up for long-term and potential effects.
Before & after care
- Swelling or bruising may appear at injection sites for about a week and usually resolves naturally.
- Do not rub or apply strong pressure to the area on the treatment day.
- Adequate moisturizing and sun protection are needed.
- Avoid sauna and hot environments for one week.
- Consultation is required during pregnancy, breastfeeding, or with certain conditions.
Frequently asked questions
Q.What is Juveacell?
Juveacell is a regenerative treatment using human acellular dermal matrix (hADM). Unlike ordinary skin boosters that 'stimulate' collagen with a single ingredient, it places a matrix resembling the skin's own dermal structure to create a scaffold for regeneration. It uses hADM decellularized by a supercritical CO₂ process, and a single session is designed to create a scaffold for regeneration.
Q.How is it different from Rejuran or Juvelook?
Rejuran and Juvelook 'stimulate' collagen production with specific ingredients (PN/PDRN, PLLA, etc.), whereas Juveacell places the dermal structure (matrix) itself as a scaffold for regeneration. It tends to give a natural result without nodules. It's not about which is better but a difference in approach — Juveacell suits under-eye and regeneration, while Rejuran/Juvelook suit texture and elasticity upkeep, decided through consultation.
Q.Does it cause nodules?
Correct — it tends not to form nodules, so it can be used on delicate areas like under the eyes where nodules are a concern. Aside from common injection reactions (temporary redness, swelling, bruising), no notable side effects have been reported.
Q.It uses human tissue — is it safe?
The source human dermis is classified in the U.S. as a human cell/tissue product (HCT/P), regulated by the FDA under 21 CFR Part 1271 and supplied by AATB-accredited tissue banks. Processing removes cellular components that could cause rejection or infection, and the surfactant-free supercritical CO₂ method further reduces chemical residue to minimize immune and foreign-body reactions. That said, because it uses human tissue, we recommend ongoing follow-up for long-term and potential effects.
Q.I heard it's especially good for under-eyes.
It is used for under-eye hollowing, dark circles, and regeneration. It is applied in a similar area to Rejuran Eye and Juvelook Eye; since the under-eye is an area where nodules are especially unwelcome and Juveacell tends not to form nodules, it can be treated here as well.
Q.How long does it last and what's the downtime?
It lasts about 3–6 months (individual variation). Anesthesia is by topical numbing cream; pain is moderate for full-face skin-booster injections and mild for cannula-based under-eye treatment. Swelling may last 2–3 days (up to 1–2 weeks at most), but you can carry on with daily life.
Consultation · 상담 안내
Is Juveacell right for you?
We’ll guide the right plan for your goals and skin — full-face, under-eye and more — in a 1:1 consultation.